Avoiding the Pitfalls of Liquid Chromatography-Mass Spectrometry in the Cannabis Lab




Anyone familiar with a cannabis lab will already be familiar with liquid chromatography-mass spectrometry (LC-MS), one of the principal tools used to detect and quantify compounds within a cannabis sample. But even those familiar with LC-MS can make mistakes.

So, to help avoid the common pitfalls of the technique, Dr Kimberly Ross, chief science officer at Peak Compliance, and Julie Kowalski of JA Kowalski Science Support outline where LC-MS can go wrong in this original Analytical Cannabis list, which highlights:

  • The importance of instrument maintenance and sample cleanup
  • How to meet regulatory LOD/LOQ requirements
  • And the effects the cannabis matrix can have on testing
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